TLR3 Antikörper

Produktnummer ABIN3029166

Produktdetails anti-TLR3 Antikörper

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: Antigen affinity purified

Immunogen: This TLR3 antibody was produced from rabbits immunized with TLR3 recombinant protein.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the TLR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the TLR3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu TLR3

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Andere Bezeichnung: TLR3 (TLR3 Produkte)

Synonyme: CD283 antikoerper, IIAE2 antikoerper, AI957183 antikoerper, zgc:123006 antikoerper, toll like receptor 3 antikoerper, toll-like receptor 3 antikoerper, TLR3 antikoerper, Tlr3 antikoerper, tlr3 antikoerper

Hintergrund: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

UniProt: O15455

Pathways: TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades