TBK1 Antikörper (AA 150-181)

Produktnummer ABIN3029094

Dieses Anti-TBK1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TBK1 in WB, ELISA und IHC. Geeignet für Human.

Kurzübersicht für TBK1 Antikörper (AA 150-181) (ABIN3029094)

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-TBK1 Antikörper

Bindungsspezifität: AA 150-181

Kreuzreaktivität (Details): Expected species reactivity: Mouse, Xenopus

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 150-181 from the human protein was used as the immunogen for this TBK1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the TBK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the TBK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu TBK1

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Andere Bezeichnung: TBK1

Hintergrund: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

UniProt: Q9UHD2

Pathways: TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interaktom