TBK1 Antikörper (AA 8-35)
Kurzübersicht für TBK1 Antikörper (AA 8-35) (ABIN3029093)
Target
Alle TBK1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 8-35
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Aufreinigung
- Antigen affinity purified
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Immunogen
- A portion of amino acids 8-35 from the mouse protein was used as the immunogen for this Tbk1 antibody.
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Isotyp
- Ig Fraction
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Applikationshinweise
- Titration of the Tbk1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot the Tbk1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- TBK1 (TANK-Binding Kinase 1 (TBK1))
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Andere Bezeichnung
- Tbk1
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Hintergrund
- Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of a TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response.
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UniProt
- Q9WUN2
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Pathways
- TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interaktom
Target
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