ROS1 Antikörper (C-Term)

Produktnummer ABIN3030232

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ROS1 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ROS1 Antikörper (C-Term) (ABIN3030232)

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ROS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-ROS1 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Antigen affinity purified

Immunogen: This ROS1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1744-1777 amino acids from the C-terminal region of human ROS1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the ROS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the ROS1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu ROS1

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Andere Bezeichnung: ROS1

Hintergrund: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

UniProt: P08922

Pathways: RTK Signalweg