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Retinoblastoma Protein (Rb) Antikörper (pSer780)

Rb Protein Reaktivität: Human ELISA, IHC, DB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3032466
  • Target Alle Retinoblastoma Protein (Rb) (Rb Protein) Antikörper anzeigen
    Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
    Bindungsspezifität
    • 15
    • 14
    • 14
    • 14
    • 13
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer780
    Reaktivität
    • 174
    • 71
    • 56
    • 8
    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 151
    • 24
    Kaninchen
    Klonalität
    • 149
    • 26
    Polyklonal
    Konjugat
    • 85
    • 17
    • 10
    • 9
    • 9
    • 9
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    Dieser Retinoblastoma Protein (Rb) Antikörper ist unkonjugiert
    Applikation
    • 89
    • 88
    • 84
    • 27
    • 26
    • 15
    • 14
    • 9
    • 2
    ELISA, Immunohistochemistry (IHC), Dot Blot (DB)
    Kreuzreaktivität (Details)
    Expected species reactivity: Mouse, Rat
    Aufreinigung
    Antigen affinity purified
    Immunogen
    This phospho-Rb antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS780 of human Rb.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product Rb Protein Primärantikörper
  • Applikationshinweise
    Titration of the phospho-Rb antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500,IHC (Paraffin): 1:50-1:100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the phospho-Rb antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
    Andere Bezeichnung
    Retinoblastoma / Rb (Rb Protein Produkte)
    Hintergrund
    RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.
    UniProt
    P06400
    Pathways
    Mitotic G1-G1/S Phases
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