PTEN Antikörper (pTyr68)

Produktnummer ABIN3032213

Der Kaninchen Polyklonal Anti-PTEN-Antikörper wurde für DB und ELISA validiert. Er ist geeignet, PTEN in Proben von Human zu detektieren.

Kurzübersicht für PTEN Antikörper (pTyr68) (ABIN3032213)

Target: PTEN (Phosphatase and Tensin Homolog (PTEN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTEN Antikörper ist unkonjugiert

Applikation: Dot Blot (DB), ELISA

Produktdetails anti-PTEN Antikörper

Bindungsspezifität: pTyr68

Kreuzreaktivität (Details): Expected species reactivity: Mouse, Xenopus

Aufreinigung: Antigen affinity purified

Immunogen: This phospho-PTEN antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY68 of human PTEN.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the phospho-PTEN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the phospho-PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu PTEN

Target: PTEN (Phosphatase and Tensin Homolog (PTEN))

Andere Bezeichnung: PTEN

Hintergrund: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

UniProt: P60484

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagie, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling