PARP1 Antikörper (pSer864)

Produktnummer ABIN3032272

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PARP1 in ELISA und DB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für PARP1 Antikörper (pSer864) (ABIN3032272)

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARP1 Antikörper ist unkonjugiert

Applikation: ELISA, Dot Blot (DB)

Produktdetails anti-PARP1 Antikörper

Bindungsspezifität: pSer864

Verwendungszweck: Phospho-PARP1 Antibody (pS864)

Homologie: Mouse,Rat,Bovine,Hamster

Aufreinigung: Antigen affinity purified

Immunogen: This Phospho-PARP1 (S864) Antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS864 of human PARP1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Phospho-PARP1 (S864) Antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Phospho-PARP1 (S864) Antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu PARP1

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Andere Bezeichnung: PARP

Hintergrund: Phospho-PARP1 (S864) Antibody specifically detects PARP1 phosphorylated at the serine 864 site. This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Phosphorylation-dependent PARP1 signaling studies may also benefit from our < a href=../tds/phospho-parp-antibody-ps177-f48726>phospho-PARP1 (Ser177) antibody page focused on DNA damage response and chromatin stress pathway regulation.

UniProt: P09874

Pathways: Apoptose, Caspase Kaskade in der Apoptose, DNA Reparatur, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location