MAP2 Antikörper (pSer1539)

Produktnummer ABIN3031685

Der Kaninchen Polyklonal Anti-MAP2-Antikörper wurde für ELISA und DB validiert. Er ist geeignet, MAP2 in Proben von Human zu detektieren.

Kurzübersicht für MAP2 Antikörper (pSer1539) (ABIN3031685)

Target: MAP2 (Microtubule-Associated Protein 2 (MAP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP2 Antikörper ist unkonjugiert

Applikation: ELISA, Dot Blot (DB)

Produktdetails anti-MAP2 Antikörper

Bindungsspezifität: pSer1539

Kreuzreaktivität (Details): Expected species reactivity: Mouse, Rat

Aufreinigung: Antigen affinity purified

Immunogen: This phospho-MAP2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS1539 of human MAP2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the phospho-MAP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the phospho-MAP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu MAP2

Target: MAP2 (Microtubule-Associated Protein 2 (MAP2))

Andere Bezeichnung: MAP2

Hintergrund: MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2, two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton.

UniProt: P11137