NEUROD1 Antikörper (AA 15-45)

Produktnummer ABIN3031977

Dieses Anti-NEUROD1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von NEUROD1 in WB, ELISA, IHC und IF. Geeignet für Human.

Kurzübersicht für NEUROD1 Antikörper (AA 15-45) (ABIN3031977)

Target: NEUROD1 (Neuronal Differentiation 1 (NEUROD1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NEUROD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-NEUROD1 Antikörper

Bindungsspezifität: AA 15-45

Aufreinigung: Purified

Immunogen: A portion of amino acids 15-45 from the human protein was used as the immunogen for this NeuroD1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the NeuroD1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the NeuroD1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu NEUROD1

Target: NEUROD1 (Neuronal Differentiation 1 (NEUROD1))

Andere Bezeichnung: NeuroD1

Hintergrund: NeuroD1 acts as a differentiation factor during neurogenesis. They are expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation. NeuroD1 is a basic helix-loop-helix (bHLH) protein contain 1 bHLH domain. NeuroD1 is a transcriptional activator, for efficient DNA binding it requires dimerization with another bHLH protein. It was reported that NeuroD1 involves heterodimerization with the ubiquitous bHLH protein E47, and regulates insulin gene expression by binding to a critical E-box motif on the insulin promoter. Defects in NEUROD1 causes maturity onset diabetes of the young type VI. MODY6 is a form of non-insulin-dependent diabetes mellitus (NIDDM) characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.

UniProt: Q13562

Pathways: Dopaminergic Neurogenesis, Hormone Transport, Carbohydrate Homeostasis