MGMT Antikörper (AA 1-30)
Kurzübersicht für MGMT Antikörper (AA 1-30) (ABIN3032084)
Target
Alle MGMT Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 1-30
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Verwendungszweck
- MGMT Antibody
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Aufreinigung
- Antigen affinity
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Immunogen
- A portion of amino acids 1-30 from the human protein was used as the immunogen for this MGMT antibody.
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Isotyp
- Ig Fraction
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Applikationshinweise
- Titration of the MGMT antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot the MGMT antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- MGMT (O6-Methylguanine-DNA-Methyltransferase (MGMT))
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Andere Bezeichnung
- MGMT
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Hintergrund
- MGMT is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
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UniProt
- P16455
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Pathways
- DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus
Target
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