MEF2C Antikörper (AA 278-307)

Produktnummer ABIN3031904

Der Kaninchen Polyklonal Anti-MEF2C-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, MEF2C in Proben von Human zu detektieren.

Kurzübersicht für MEF2C Antikörper (AA 278-307) (ABIN3031904)

Target: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MEF2C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-MEF2C Antikörper

Bindungsspezifität: AA 278-307

Kreuzreaktivität (Details): Expected species reactivity: Mouse, Bovine, Pig

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 278-307 from the human protein was used as the immunogen for this MEF2C antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the MEF2C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the MEF2C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu MEF2C

Target: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Andere Bezeichnung: MEF2C

Hintergrund: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2. [UniProt]

UniProt: Q06413

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, BCR Signaling