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MEF2C Antikörper (AA 278-307)

Der Kaninchen Polyklonal Anti-MEF2C-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, MEF2C in Proben von Human zu detektieren.
Produktnummer ABIN3031904

Kurzübersicht für MEF2C Antikörper (AA 278-307) (ABIN3031904)

Target

Alle MEF2C Antikörper anzeigen
MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Reaktivität

  • 155
  • 70
  • 46
  • 6
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 152
  • 9
  • 1
Kaninchen

Klonalität

  • 151
  • 11
Polyklonal

Konjugat

  • 85
  • 10
  • 9
  • 9
  • 8
  • 7
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser MEF2C Antikörper ist unkonjugiert

Applikation

  • 127
  • 83
  • 48
  • 33
  • 17
  • 15
  • 7
  • 7
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • Bindungsspezifität

    • 34
    • 29
    • 10
    • 10
    • 10
    • 8
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 278-307

    Kreuzreaktivität (Details)

    Expected species reactivity: Mouse, Bovine, Pig

    Aufreinigung

    Antigen affinity purified

    Immunogen

    A portion of amino acids 278-307 from the human protein was used as the immunogen for this MEF2C antibody.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    Titration of the MEF2C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Aliquot the MEF2C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target

    MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

    Andere Bezeichnung

    MEF2C

    Hintergrund

    Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2. [UniProt]

    UniProt

    Q06413

    Pathways

    Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, BCR Signaling
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