IRF3 Antikörper (AA 46-72)
Kurzübersicht für IRF3 Antikörper (AA 46-72) (ABIN3031417)
Target
Alle IRF3 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 46-72
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Kreuzreaktivität (Details)
- Expected species reactivity: Bovine, Pig
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Aufreinigung
- Antigen affinity purified
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Immunogen
- A portion of amino acids 46-72 from the mouse protein was used as the immunogen for this Irf3 antibody.
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Isotyp
- Ig Fraction
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anti-Interferon Regulatory Factor 3 (IRF3) (pSer396) antibody
IRF3 Reaktivität: Human, Maus, Ratte, Affe WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-260) antibodyIRF3 Reaktivität: Human WB, IHC, IF, ChIP Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-452) antibodyIRF3 Reaktivität: Human WB, ELISA, IF, IP Wirt: Maus Monoclonal 3C8 unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-360) antibodyIRF3 Reaktivität: Human WB, IHC, IP, ICC, FACS Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (AA 51-150) antibodyIRF3 Reaktivität: Human, Maus, Ratte, Affe, Rind (Kuh) WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (C-Term) antibodyIRF3 Reaktivität: Human WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (pSer386) antibodyIRF3 Reaktivität: Human, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (AA 1268-1341) antibodyIRF3 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-452) antibodyIRF3 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (pSer385) antibodyIRF3 Reaktivität: Human, Maus, Ratte WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- Titration of the Irf3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot the Irf3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- IRF3 (Interferon Regulatory Factor 3 (IRF3))
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Andere Bezeichnung
- Irf3
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Hintergrund
- Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).
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UniProt
- P70671
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Pathways
- TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
Target
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