HSPD1 Antikörper (AA 80-109)

Produktnummer ABIN3031151

Produktdetails anti-HSPD1 Antikörper

Target: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Bindungsspezifität: AA 80-109

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSPD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: Purified

Immunogen: A portion of amino acids 80-109 from the human protein was used as the immunogen for this HSP60 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the HSP60 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the HSP60 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu HSPD1

Target: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Andere Bezeichnung: HSP60 (HSPD1 Produkte)

Synonyme: CPN60 antikoerper, GROEL antikoerper, HLD4 antikoerper, HSP-60 antikoerper, HSP60 antikoerper, HSP65 antikoerper, HuCHA60 antikoerper, SPG13 antikoerper, chaperonin antikoerper, cpn60 antikoerper, groel antikoerper, hld4 antikoerper, hsp60 antikoerper, hsp65 antikoerper, spg13 antikoerper, 60kDa antikoerper, Hsp60 antikoerper, 12 antikoerper, BP5 antikoerper, CG12101 antikoerper, Cpn60 antikoerper, Dmel\\CG12101 antikoerper, Dmhsp60 antikoerper, G62 antikoerper, HSP60A antikoerper, Hsp60A antikoerper, IEF16 antikoerper, Mmp-P1 antikoerper, SSP 7506 antikoerper, d-hsp60 antikoerper, hsp60A antikoerper, l(1)10Ac antikoerper, l(1)BP5 antikoerper, l(1)G8 antikoerper, l(1)HM21 antikoerper, l(1)L12 antikoerper, l(1)dp025 antikoerper, cb863 antikoerper, fa04a05 antikoerper, fb22d10 antikoerper, fi27b05 antikoerper, id:ibd2197 antikoerper, sb:cb144 antikoerper, wu:fa04a05 antikoerper, wu:fb22d10 antikoerper, wu:fi04a12 antikoerper, wu:fi27b05 antikoerper, MIF4 antikoerper, MNA2 antikoerper, mopA antikoerper, groL antikoerper, crpA antikoerper, Hspd1-30p antikoerper, heat shock protein family D (Hsp60) member 1 antikoerper, heat shock protein family D (Hsp60) member 1 S homeolog antikoerper, 60 kDa heat shock protein, mitochondrial antikoerper, heat shock protein 1 (chaperonin) antikoerper, Heat shock protein 60A antikoerper, heat shock 60 protein 1 antikoerper, chaperone ATPase HSP60 antikoerper, molecular chaperone GroEL antikoerper, thermosome subunit antikoerper, chaperonin GroEL antikoerper, mitochondrial chaperonin antikoerper, heat shock protein family D member 1 antikoerper, HSPD1 antikoerper, hspd1.S antikoerper, hspd1 antikoerper, LOC100414401 antikoerper, Hspd1 antikoerper, Hsp60A antikoerper, HSP60 antikoerper, groEL antikoerper, MMP_RS07785 antikoerper, groEl antikoerper, LOC100136430 antikoerper

Hintergrund: Hsp60 is a member of a highly conserved family which includes molecular chaperones from several species such as plant Hsp60 (known as Rubisco binding protein), GroEL, the E.coli Hsp60 and 65 kDa major antigen of mycobacteria. In eukaryotes, Hsp60 is localized in the mitochondrial matrix and in plants Hsp60 is localized in the chloroplast. Mitochondria, chloroplasts and bacteria have a common ancestry (>1 billion years) and this fact together with the high degree of homology between the divegent Hsp60s would indicate that these proteins carry out a primitive but important function which is similar to all of these different species.The common characteristics of the Hsp60s from the divergent species are i) high abundance, ii) induction with environmental stress such as heat shock, iii) homo oligomeric structures of either 7 or 14 subunits which reversibly dissociate in the presence of magnesium ions and ATP, iv) ATPase activity and v) a role in folding and assembly of oligomeric protein structures. These similarities are supported by recent studies where the single ring human mitochondrial homolog, Hsp60 with its co chaperonin, Hsp10 were expressed in a E. coli strain, engineered so that the groE operon is under strict regulatory control. This study has demonstrated that expression of Hsp60-Hsp10 was able to carry out all essential in vivo functions of GroEL and its co chaperonin, GroES. Consistent with their functions as chaperones, Hsp60 and Hsp10 have been suggested to act as docking molecules with a passive role in the maturation of caspase processing. Data demonstrates that recombinant Hsp60 and Hsp10 have been shown to accelerate the activation of procaspase 3 by cytochrome c and dATP in an ATP dependent manner. Hsps are intracellular proteins which are thought to serve protective functions against infection and cellular stress, however several recent studies indicate that members of the Hsp60 family are linked to a number of autoimmune diseases, artherosclerosis and chlamydial disease.

UniProt: Q0VDF9

Pathways: Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity