GFAP Antikörper (N-Term)

Produktnummer ABIN3028680

Der Kaninchen Polyklonal anti-GFAP Antikörper (ABIN3028680) detektiert spezifisch GFAP in WB, IHC und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Zebrafisch (Danio rerio).

Kurzübersicht für GFAP Antikörper (N-Term) (ABIN3028680)

Target: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-GFAP Antikörper

Bindungsspezifität: AA 2-36, N-Term

Verwendungszweck: Zebrafish Gfap Antibody

Aufreinigung: Antigen affinity

Immunogen: This Gfap antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 2-36 amino acids from the N-terminal region of zebrafish Gfap.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Gfap antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Gfap antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu GFAP

Target: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Andere Bezeichnung: Gfap

Hintergrund: Glial fibrillary acidic protein (GFAP) is a major intermediate filament protein expressed in astroglial cells and radial glia of the central nervous system (CNS). In zebrafish (Danio rerio), GFAP serves as a key structural and functional component of glial cells, particularly radial glial progenitors, which play essential roles in CNS development, neurogenesis, and regeneration.

Zebrafish GFAP shares significant structural and functional homology with mammalian GFAP, including a conserved α-helical rod domain crucial for filament assembly. It is prominently expressed during embryonic development and persists in specific glial populations in the adult brain and spinal cord. Unlike in mammals, radial glia expressing GFAP remain active as neural stem cells in the adult zebrafish CNS, making GFAP an important marker for studying neurodevelopment and regeneration.

GFAP expression in zebrafish is widely used as a glial cell marker in developmental biology, neural stem cell research, and models of CNS injury and repair. Its upregulation is also indicative of reactive gliosis following CNS trauma.

UniProt: Q58EE9