DKK1 Antikörper
Kurzübersicht für DKK1 Antikörper (ABIN3030725)
Target
Alle DKK1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- DKK1 Antibody
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Aufreinigung
- Antigen affinity
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Immunogen
- This DKK1 antibody was produced from a rabbit immunized with a recombinant protein of human DKK1.
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Isotyp
- Ig Fraction
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Applikationshinweise
- Titration of the DKK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot the DKK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- DKK1 (Dickkopf Homolog 1 (DKK1))
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Andere Bezeichnung
- DKK1
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Hintergrund
- Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. [UniProt]
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UniProt
- O94907
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Pathways
- WNT Signalweg, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation
Target
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