Cyclin D2 Antikörper (AA 258-285)

Produktnummer ABIN3030594

Dieses Anti-Cyclin D2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Cyclin D2 in WB und ELISA. Geeignet für Human.

Kurzübersicht für Cyclin D2 Antikörper (AA 258-285) (ABIN3030594)

Target: Cyclin D2 (CCND2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin D2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Cyclin D2 Antikörper

Bindungsspezifität: AA 258-285

Kreuzreaktivität (Details): Expected species reactivity: Bovine, Pig

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 258-285 from the human protein was used as the immunogen for this Cyclin D2 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Cyclin D2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Cyclin D2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu Cyclin D2

Target: Cyclin D2 (CCND2)

Hintergrund: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

UniProt: P30279

Pathways: Zellzyklus, Mitotic G1-G1/S Phases