Cyclin D1 Antikörper (AA 203-238)

Produktnummer ABIN3029709

Dieses Anti-Cyclin D1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Cyclin D1 in WB, ELISA und IF. Geeignet für Human.

Kurzübersicht für Cyclin D1 Antikörper (AA 203-238) (ABIN3029709)

Target: Cyclin D1 (CCND1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin D1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-Cyclin D1 Antikörper

Bindungsspezifität: AA 203-238

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 203-238 from the human protein was used as the immunogen for this Cyclin D antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Cyclin D antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Cyclin D antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu Cyclin D1

Target: Cyclin D1 (CCND1)

Hintergrund: CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb.

UniProt: P24385

Pathways: PI3K-Akt Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, ER-Nucleus Signaling