MME Antikörper (AA 272-300)

Produktnummer ABIN3031748

Der Maus Monoklonal Anti-MME-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, MME in Proben von Human zu detektieren.

Kurzübersicht für MME Antikörper (AA 272-300) (ABIN3031748)

Target: MME (Membrane Metallo-Endopeptidase (MME))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MME Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 307CT12-12-5

Produktdetails anti-MME Antikörper

Bindungsspezifität: AA 272-300

Aufreinigung: Purified

Immunogen: A portion of amino acids 272-300 from the human protein was used as the immunogen for this CD10 antibody.

Isotyp: IgM kappa

Anwendungsinformationen

Applikationshinweise: Titration of the CD10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:100-1:250

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the CD10 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Andere Bezeichnung: CD10

Substanzklasse: Chemical

Hintergrund: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85 % of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq].

UniProt: P08473

Pathways: RTK Signalweg, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration