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Axin Antikörper (AA 330-359)
AXIN1
Reaktivität: Human
WB, ELISA
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN3030088
Produktdetails anti-Axin Antikörper
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Target
Alle Axin (AXIN1) Antikörper anzeigen
Axin (AXIN1)
(Axin 1 (AXIN1))
Bindungsspezifität
Alle Epitope für Axin Antikörper
AA 330-359
Reaktivität
Alle Reaktivitäten für Axin Antikörper
Human
Wirt
Alle Wirte für Axin Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für Axin Antikörper
Polyklonal
Konjugat
Alle Konjugate für Axin Antikörper
Dieser Axin Antikörper ist unkonjugiert
Applikation
Alle Applikationen für Axin Antikörper
Western Blotting (WB), ELISA
Kreuzreaktivität (Details)
Expected species reactivity: Mouse, Rat
Aufreinigung
Antigen affinity purified
Immunogen
A portion of amino acids 330-359 from the human protein was used as the immunogen for this AXIN1 antibody.
Isotyp
Ig Fraction
Top Product
Discover our top product AXIN1 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Titration of the AXIN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Aliquot the AXIN1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Details zu Axin
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Target
Axin (AXIN1)
(Axin 1 (AXIN1))
Andere Bezeichnung
AXIN1 (AXIN1 Produkte )
Synonyme
AXIN1 antikoerper, axin antikoerper, fused antikoerper, xAxin antikoerper, LOC100226467 antikoerper, AXIN antikoerper, PPP1R49 antikoerper, AI316800 antikoerper, Axin antikoerper, Fu antikoerper, Kb antikoerper, Ki antikoerper, kinky antikoerper, knobbly antikoerper, AXIN1-RGS antikoerper, wu:fi22e03 antikoerper, wu:fj14c08 antikoerper, wu:fk11b03 antikoerper, zgc:109872 antikoerper, axin 1 antikoerper, axin 1 S homeolog antikoerper, axin 1 L homeolog antikoerper, AXIN1 antikoerper, axin1.S antikoerper, axin1.L antikoerper, Axin1 antikoerper, axin1 antikoerper
Hintergrund
AXIN1 is a component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects, down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. [UniProt]
UniProt
O15169
Pathways
WNT Signalweg , Sensory Perception of Sound , Regulation of G-Protein Coupled Receptor Protein Signaling
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