FSHR Antikörper (full length)

Produktnummer ABIN4949699

Der Maus Monoklonal anti-FSHR Antikörper (Klon FSHR-1400) (ABIN4949699) detektiert spezifisch FSHR in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für FSHR Antikörper (full length) (ABIN4949699)

Target: FSHR (Follicle Stimulating Hormone Receptor (FSHR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FSHR Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: FSHR-1400

Produktdetails anti-FSHR Antikörper

Bindungsspezifität: full length

Verwendungszweck: FSHR Antibody / FSH Receptor (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: A human full length recombinant protein was used as the immunogen for this FSHR antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the FSHR antibody to be titered up or down for optimal performance.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the FSHR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu FSHR

Target: FSHR (Follicle Stimulating Hormone Receptor (FSHR))

Andere Bezeichnung: FSHR

Hintergrund: Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its alpha and beta subunits. While the alpha subunit of FSH is involved in the binding of FSH to the receptor, the beta subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome, a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.

UniProt: P23945

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Platelet-derived growth Factor Receptor Signaling