BAFF Antikörper

Produktnummer ABIN4949453

Dieser Anti-BAFF-Antikörper ist ein Maus-Monoklonal-Antikörper zum Nachweis von BAFF in FACS und IF. Geeignet für Human.

Kurzübersicht für BAFF Antikörper (ABIN4949453)

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BAFF Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: C257-1638

Produktdetails anti-BAFF Antikörper

Aufreinigung: Protein G affinity chromatography

Immunogen: Recombinant human BAFF protein was used as the immunogen for this BAFF antibody.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Titering of the BAFF antibody may be required for optimal performance.\. FACS: 0.5-1 μg/million cells,IF: 1-2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in sterile PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: BAFF antibody with azide can be stored at 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu BAFF

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Andere Bezeichnung: BAFF / BLyS

Hintergrund: BAFF/BLyS/CD257 is a type II transmembrane protein, and a member of the tumor necrosis factor ligand superfamily. It is proteolytically cleaved to form a soluble protein. BAFF, like other TNF ligand family members, forms homo-trimers. The predicted molecular weight of a BAFF monomer is approximately 31  kDa. It is expressed on peripheral blood B and T lymphocytes, monocytes, macrophages, and dendritic cells and is upregulated by IFN-gamma and down-regulated by PMA/ionomycin treatment. BAFF stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors, BAFF prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3).

Pathways: NF-kappaB Signalweg, Production of Molecular Mediator of Immune Response