PD-1 Antikörper

Produktnummer ABIN492542

Der Maus Monoklonal anti-PD-1 Antikörper wird verwendet zum Nachweis von PD-1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC (p) und EIA.

Kurzübersicht für PD-1 Antikörper (ABIN492542)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PD-1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Klon: 12A7D7

Produktdetails anti-PD-1 Antikörper

Spezifität: This antibody detects CD279 / PD1.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Produktmerkmale: Synonyms: Protein PD-1, hPD-1, PDCD1, Programmed cell death protein 1

Aufreinigung: Affinity chromatography

Immunogen: ~150 amino acid recombinant protein of mouse PD-1Remarks: GenBank accession no. NP_032824

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot at 1 - 2 μg/mL. A-20 cell lysate can be used as positive control. ELISA. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Andere Bezeichnung: CD279 / PD1

Hintergrund: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of Synonyms: PDCD1, Programmed cell death protein 1, Protein PD-1, hPD-1

Gen-ID: 18566

UniProt: Q02242

Pathways: Cancer Immune Checkpoints