ORAI3 Antikörper (C-Term)

Produktnummer ABIN492535

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ORAI3 in WB, IHC (p) und EIA. Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für ORAI3 Antikörper (C-Term) (ABIN492535)

Target: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ORAI3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Klon: 2H2G9

Produktdetails anti-ORAI3 Antikörper

Bindungsspezifität: C-Term

Spezifität: Recognizes ORAI3. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE, these may represent post-translationally modified ORAI3.

Produktmerkmale: Synonyms: TMEM142C, ORAI-3, Transmembrane Protein 142C

Aufreinigung: Immunoaffinity Chromotography.

Immunogen: A 19 amino acid peptide from near the carboxy terminus of Human ORAI3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: ORAI3 antibody can be used for detection of ORAI3 at 2-4 μg/mL. Immunohistochemistry: 2.5 μg/mL. Positive Control: Rat spleen tissue lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu ORAI3

Target: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Andere Bezeichnung: ORAI3

Hintergrund: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2 (5). Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter.Synonyms: ORAI-3, TMEM142C, Transmembrane Protein 142C

Gen-ID: 93129

UniProt: Q9BRQ5