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RPS6KA1 Antikörper

Dieses Maus Monoklonal-Antikörper erkennt spezifisch RPS6KA1 in WB. Er zeigt eine Reaktivität gegenüber Human und Maus.
Produktnummer ABIN4913779

Kurzübersicht für RPS6KA1 Antikörper (ABIN4913779)

Target

Alle RPS6KA1 Antikörper anzeigen
RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))

Reaktivität

  • 190
  • 102
  • 75
  • 6
  • 5
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 196
  • 17
Maus

Klonalität

  • 170
  • 44
Monoklonal

Konjugat

  • 105
  • 13
  • 12
  • 10
  • 6
  • 6
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
Dieser RPS6KA1 Antikörper ist unkonjugiert

Applikation

  • 172
  • 93
  • 54
  • 53
  • 50
  • 26
  • 24
  • 21
  • 12
  • 11
  • 9
  • 2
  • 2
  • 2
Western Blotting (WB)

Klon

5C1
  • Kreuzreaktivität

    Human, Maus

    Aufreinigung

    Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

    Immunogen

    This RPS6KA1 monoclonal antibody is generated from mouse immunized with RPS6KA1 recombinant protein.

    Isotyp

    IgG1
  • Applikationshinweise

    WB 1:300-5000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.5 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))

    Andere Bezeichnung

    RPS6KA1

    Hintergrund

    Synonyms: RSK, HU-1, RSK1, p90Rsk, MAPKAPK1A, Ribosomal protein S6 kinase alpha-1, S6K-alpha-1, 90 kDa ribosomal protein S6 kinase 1, p90-RSK 1, p90RSK1, p90S6K, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, Ribosomal S6 kinase 1, RSK-1, RPS6KA1

    Background: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function.

    Gen-ID

    6195

    UniProt

    Q15418

    Pathways

    MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades
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