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CYLD Antikörper

CYLD Reaktivität: Human WB, FACS Wirt: Maus Monoclonal 7C1 unconjugated
Produktnummer ABIN4908488
  • Target Alle CYLD Antikörper anzeigen
    CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))
    Reaktivität
    • 40
    • 24
    • 18
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 35
    • 5
    • 1
    Maus
    Klonalität
    • 36
    • 5
    Monoklonal
    Konjugat
    • 23
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CYLD Antikörper ist unkonjugiert
    Applikation
    • 32
    • 15
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Kreuzreaktivität
    Human
    Aufreinigung
    Purified by Protein G.
    Immunogen
    This CYLD antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 305-582 amino acids from human CYLD.
    Klon
    7C1
    Isotyp
    IgG2a
    Top Product
    Discover our top product CYLD Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    FCM 1:20-100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))
    Andere Bezeichnung
    CYLD (CYLD Produkte)
    Synonyme
    BRSS antikoerper, CDMT antikoerper, CYLD1 antikoerper, CYLDI antikoerper, EAC antikoerper, MFT antikoerper, MFT1 antikoerper, SBS antikoerper, TEM antikoerper, USPL2 antikoerper, 2010013M14Rik antikoerper, 2900009M21Rik antikoerper, C130039D01Rik antikoerper, mKIAA0849 antikoerper, cyld antikoerper, LRRGT00003 antikoerper, Rp1 antikoerper, Rp1h antikoerper, CYLD lysine 63 deubiquitinase antikoerper, cylindromatosis (turban tumor syndrome), a antikoerper, CYLD antikoerper, Cyld antikoerper, cylda antikoerper
    Hintergrund

    Synonyms: EAC, MFT, SBS, TEM, BRSS, CDMT, MFT1, CYLD1, CYLDI, USPL2, Ubiquitin carboxyl-terminal hydrolase CYLD, Deubiquitinating enzyme CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD, CYLD, KIAA0849, HSPC057

    Background: Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane, this process does not depend on NF-kappa-B activation (By similarity).

    Gen-ID
    1540
    UniProt
    Q9NQC7
    Pathways
    Apoptose, Activation of Innate immune Response
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