CD46 Antikörper

Produktnummer ABIN4889041

Dieser Maus Monoklonal Antikörper erkennt spezifisch CD46 in WB, FACS, ELISA und IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CD46 Antikörper (ABIN4889041)

Target: CD46

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD46 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 3F1

Produktdetails anti-CD46 Antikörper

Spezifität: Reacts with human 44 kDa CD46 protein

Kreuzreaktivität (Details): Diffuse and duplicated bands can be seen due to the glycosylation of CD46.

Aufreinigung: Purified (protein A)

Immunogen: Recombinant CD46 protein

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA1:20 000 - 1:100 000 IHC-P10 μg/mL WB1:2000 - 1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Must be reconstituted in distilled water.

Konzentration: 1 mg/mL

Buffer: PBS

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Haltbarkeit: 24 months

Details zu CD46

Target: CD46

Andere Bezeichnung: CD46 / Membrane Cofactor Protein

Hintergrund: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Gen-ID: 4179

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization