RECQL2 Antikörper (AA 122-240)

Produktnummer ABIN4886768

Produktdetails anti-RECQL2 Antikörper

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Bindungsspezifität: AA 122-240

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RECQL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Werner syndrome ATP-dependent helicase(WRN) detection. Tested with WB in Human,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Werner syndrome ATP-dependent helicase(WRN) detection. Tested with WB in Human,Rat.
Gene Name: Werner syndrome RecQ like helicase
Protein Name: Werner syndrome ATP-dependent helicase

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human WRN recombinant protein (Position: Q122-N240). Human WRN shares 84% amino acid (aa) sequence identity with mouse WRN.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu RECQL2

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Andere Bezeichnung: WRN (WRN Produkte)

Synonyme: RECQ3 antikoerper, RECQL2 antikoerper, RECQL3 antikoerper, xBLM antikoerper, recq2 antikoerper, recql2 antikoerper, recql3 antikoerper, AI846146 antikoerper, ffa-1 antikoerper, xwrn antikoerper, RGD1564788 antikoerper, Werner syndrome RecQ like helicase antikoerper, mediator of RNA polymerase II transcription subunit 34 antikoerper, Bloom syndrome RecQ like helicase antikoerper, Werner syndrome, RecQ helicase-like L homeolog antikoerper, WRN antikoerper, LOC9327212 antikoerper, blm antikoerper, Wrn antikoerper, wrn.L antikoerper

Hintergrund: Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that in humans is encoded by the WRN gene. This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

Synonyms: Exonuclease WRN | RecQ3 | RECQL2 | RECQL3 | WRN | Q14191

Gen-ID: 7486

UniProt: Q14191

Pathways: DNA Reparatur