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VASP Antikörper (N-Term)

VASP Reaktivität: Human, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN4886759
  • Target Alle VASP Antikörper anzeigen
    VASP (Vasodilator-Stimulated phosphoprotein (VASP))
    Bindungsspezifität
    • 15
    • 15
    • 14
    • 8
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 78-114, N-Term
    Reaktivität
    • 116
    • 52
    • 47
    • 11
    • 8
    • 8
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Ratte
    Wirt
    • 97
    • 18
    • 2
    Kaninchen
    Klonalität
    • 92
    • 25
    Polyklonal
    Konjugat
    • 73
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser VASP Antikörper ist unkonjugiert
    Applikation
    • 90
    • 44
    • 43
    • 29
    • 20
    • 15
    • 13
    • 13
    • 13
    • 11
    • 5
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Verwendungszweck
    Anti-VASP Antibody Picoband®
    Sequenz
    NFHQWRDARQ VWGLNFGSKE DAAQFAAGMA SALEALE
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-VASP Antibody Picoband® (ABIN4886759). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human VASP, different from the related mouse sequence by four amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product VASP Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Rat
    1. Zimmer M, Fink T, Fischer L, Hauser W, Scherer K, Lichter P, Walter U (January 1997). "Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization". Genomics. 36 (2): 227-33. 2. Harbeck, B, Hüttelmaier S, Schluter K, Jockusch B M, Illenberger S (October 2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin". J. Biol. Chem. UNITED STATES.275 (40): 30817-25. 3. Reinhard, M, Giehl K, Abel K, Haffner C, Jarchau T, Hoppe V, Jockusch B M, Walter U (April 1995). "The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins". EMBO J. ENGLAND.14 (8): 1583-9.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    VASP (Vasodilator-Stimulated phosphoprotein (VASP))
    Andere Bezeichnung
    VASP (VASP Produkte)
    Hintergrund

    Synonyms: Vasodilator-stimulated phosphoprotein,VASP,VASP,

    Tissue Specificity: Highly expressed in platelets. .

    Background: Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.

    Molekulargewicht
    40 kDa
    Gen-ID
    7408
    UniProt
    P50552
    Pathways
    T-Zell Rezeptor Signalweg, Regulation of Actin Filament Polymerization, Tube Formation
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