MEF2A Antikörper (C-Term)

Produktnummer ABIN4886665

Produktdetails anti-MEF2A Antikörper

Target: MEF2A (Myocyte Enhancer Factor 2A (MEF2A))

Bindungsspezifität: AA 466-507, C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MEF2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Verwendungszweck: Anti-MEF2A Antibody Picoband®

Sequenz: DGSDREDPRG DFHSPIVLGR PPNTEDRESP SVKRMRMDAW

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-MEF2A Antibody Picoband® (ABIN4886665). Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MEF2A, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
1. Bhagavatula, M. R. K., Fan, C., Shen, G.-Q., Cassano, J., Plow, E. F., Topol, E. J., Wang, Q. Transcription factor MEF2A mutations in patients with coronary artery disease. Hum. Molec. Genet. 13: 3181-3188, 2004. 2. Flavell, S. W., Cowan, C. W., Kim, T.-K., Greer, P. L., Lin, Y., Paradis, S., Griffith, E. C., Hu, L. S., Chen, C., Greenberg, M. E. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science 311: 1008-1012, 2006. 3. Gonzalez, P., Garcia-Castro, M., Reguero, J. R., Batalla, A., Ordonez, A. G., Palop, R. L., Lozano, I., Montes, M., Alvarez, V., Coto, E. The pro279leu variant in the transcription factor MEF2A is associated with myocardial infarction. (Letter) J. Med. Genet. 43: 167-169, 2006.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu MEF2A

Target: MEF2A (Myocyte Enhancer Factor 2A (MEF2A))

Andere Bezeichnung: MEF2A (MEF2A Produkte)

Hintergrund:

Synonyms: Myocyte-specific enhancer factor 2A,Serum response factor-like protein 1,MEF2A,MEF2,

Tissue Specificity: Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined. .

Background: Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. It is mapped to 15q26. The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 56 kDa

Gen-ID: 4205

UniProt: Q02078

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades