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Diazepam Binding Inhibitor Antikörper (AA 2-87)

Der Kaninchen Polyklonal Anti-Diazepam Binding Inhibitor-Antikörper wurde für WB, IHC, ICC, IF, FACS und IHC (fro) validiert. Er ist geeignet, Diazepam Binding Inhibitor in Proben von Human zu detektieren.
Produktnummer ABIN4886558

Kurzübersicht für Diazepam Binding Inhibitor Antikörper (AA 2-87) (ABIN4886558)

Target

Alle Diazepam Binding Inhibitor (DBI) Antikörper anzeigen
Diazepam Binding Inhibitor (DBI)

Reaktivität

  • 41
  • 16
  • 6
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 45
  • 4
Kaninchen

Klonalität

  • 46
  • 3
Polyklonal

Konjugat

  • 27
  • 9
  • 5
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Diazepam Binding Inhibitor Antikörper ist unkonjugiert

Applikation

  • 37
  • 28
  • 15
  • 13
  • 8
  • 5
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2-87

    Verwendungszweck

    Anti-Diazepam Binding Inhibitor/DBI Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Diazepam Binding Inhibitor/DBI Antibody Picoband® (ABIN4886558). Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E. coli-derived human DBI recombinant protein (Position: S2-I87). Human DBI shares 77.9% amino acid (aa) sequence identity with both mouse and rat DBI.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human
    Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. "Entrez Gene: DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)". 2. Mandrup S, Hummel R, Ravn S, et al. (1993). "Acyl-CoA-binding protein/diazepam-binding inhibitor gene and pseudogenes. A typical housekeeping gene family". J. Mol. Biol. 228 (3): 1011-22. 3. Todd S, Naylor SL (Dec 1992). "New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon-beta 3 gene, and the diazepam binding inhibitor gene". Somat Cell Mol Genet. 18(4): 381-5.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    Diazepam Binding Inhibitor (DBI)

    Andere Bezeichnung

    DBI

    Hintergrund

    Synonyms: Acyl-CoA-binding protein,ACBP,Diazepam-binding inhibitor,DBI,Endozepine,EP,DBI,

    Tissue Specificity: Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart. .

    Background: Acyl-CoA-binding protein is a protein that in humans is encoded by the DBI gene. This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.

    Molekulargewicht

    10 kDa

    Gen-ID

    1622

    UniProt

    P07108
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