APOA1 Antikörper (AA 25-267)

Produktnummer ABIN4886466

Produktdetails anti-APOA1 Antikörper

Target: APOA1 (Apolipoprotein A-I (APOA1))

Bindungsspezifität: AA 25-267

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APOA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Apolipoprotein A-I(APOA1) detection. Tested with WB, IHC-P, ELISA in Human.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Apolipoprotein A-I(APOA1) detection. Tested with WB, IHC-P, ELISA in Human.
Gene Name: apolipoprotein A-I
Protein Name: Apolipoprotein A-I

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human APOA1 recombinant protein (Position: D25-Q267). Human APOA1 shares 64% and 61.7% amino acid (aa) sequence identity with mouse and rat APOA1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human

Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu APOA1

Target: APOA1 (Apolipoprotein A-I (APOA1))

Andere Bezeichnung: APOA1 (APOA1 Produkte)

Synonyme: Alp-1 antikoerper, Apoa-1 antikoerper, Brp-14 antikoerper, Ltw-1 antikoerper, Lvtw-1 antikoerper, Sep-1 antikoerper, Sep-2 antikoerper, Sep2 antikoerper, apoA-I antikoerper, apoa antikoerper, apoa1 antikoerper, cb49 antikoerper, wu:fb33f01 antikoerper, zgc:103718 antikoerper, MGC64335 antikoerper, MGC89745 antikoerper, Apo-AI antikoerper, ApoA-I antikoerper, APOA1 antikoerper, LOC100136573 antikoerper, apoa-i antikoerper, ApoAI antikoerper, apolipoprotein A1 antikoerper, apolipoprotein A-I antikoerper, apolipoprotein A-Ia antikoerper, apolipoprotein A-I S homeolog antikoerper, apolipoprotein A4 antikoerper, APOA1 antikoerper, Apoa1 antikoerper, apoa1a antikoerper, apoa1.S antikoerper, apoa1 antikoerper, LOC100136573 antikoerper, apoa-i antikoerper, apoa4 antikoerper

Hintergrund: Apolipoprotein A-1, also known as APOA1, is a human protein with a specific role in lipid metabolism. It binds to lipopolysaccharide or endotoxin, and has a major role in the anti-endotoxin function of HDL. The gene is mapped to 11q23. And it is a single polypeptide chain with 243 amino acid residues of known primary amino acid sequence. The ApoA-I protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I is also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Additionally, ApoA-I overexpression promotes macrophage-specific reverse cholesterol transport.

Synonyms: Apo AI | APOA 1 | ApoA I | APOA1 | ApoA-I | Apo-AI | Apolipoprotein A I | Apolipoprotein A1 | Apolipoprotein AI | Apolipoprotein A-I | Apolipoprotein A-I(1-242) | ProapoA-I | Proapolipoprotein A-I | Truncated apolipoprotein A-I | P02647

Gen-ID: 335

UniProt: P02647

Pathways: Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response, Lipid Metabolism