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ADO Antikörper (AA 49-261)

ADO Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN4886431
  • Target Alle ADO Antikörper anzeigen
    ADO (2-Aminoethanethiol (Cysteamine) Dioxygenase (ADO))
    Bindungsspezifität
    • 15
    • 9
    • 5
    • 2
    • 1
    AA 49-261
    Reaktivität
    • 34
    • 20
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 34
    Kaninchen
    Klonalität
    • 34
    Polyklonal
    Konjugat
    • 12
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ADO Antikörper ist unkonjugiert
    Applikation
    • 19
    • 18
    • 16
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Verwendungszweck
    Rabbit IgG polyclonal antibody for 2-aminoethanethiol dioxygenase(ADO) detection. Tested with WB in Human,Mouse,Rat.
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for 2-aminoethanethiol dioxygenase(ADO) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: 2-aminoethanethiol dioxygenase
    Protein Name: 2-aminoethanethiol dioxygenase
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E. coli-derived human ADO recombinant protein (Position: E49-E261). Human ADO shares 90.1% amino acid (aa) sequence identity with mouse ADO.
    Isotyp
    IgG
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  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    ADO (2-Aminoethanethiol (Cysteamine) Dioxygenase (ADO))
    Andere Bezeichnung
    ADO (ADO Produkte)
    Synonyme
    C10orf22 antikoerper, Gm237 antikoerper, RGD1308233 antikoerper, wu:fc32g01 antikoerper, wu:fc52c12 antikoerper, zgc:101580 antikoerper, 2-aminoethanethiol dioxygenase antikoerper, 2-aminoethanethiol (cysteamine) dioxygenase antikoerper, 2-aminoethanethiol (cysteamine) dioxygenase a antikoerper, ADO antikoerper, Ado antikoerper, LOC100351598 antikoerper, adoa antikoerper
    Hintergrund
    Human thiol dioxygenases include cysteine dioxygenase (CDO) and cysteamine (2-aminoethanethiol) dioxygenase (ADO). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine. It is demonstrated that mouse Ado has strong and specific dioxygenase activity in vitro towards cysteamine but not cysteine. Recombinant Ado was shown to bind iron. Overexpression of Ado in HepG2/C3A cells increased the production of hypotaurine from cysteamine. Similar results were found with human ADO. When endogenous expression of ADO was reduced by RNA-mediated interference, hypotaurine production decreased. It is also noted that the demonstration of high levels of ADO in brain challenges the previous assumption that most of the taurine in the brain is a consequence of CDO activity.

    Synonyms: ADO | C10orf22 | Cysteamine dioxygenase | Q96SZ5
    Gen-ID
    84890
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