Retinoblastoma 1 Antikörper (HRP)

Produktnummer ABIN4880121

Produktdetails anti-Retinoblastoma 1 Antikörper (HRP)

Target: Retinoblastoma 1 (RB1)

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Retinoblastoma 1 Antikörper ist konjugiert mit HRP

Applikation: Bitte anfragen

Spezifität: This antibody recognises retinoblastoma-associated protein (RB), a 105 kDa tumour suppressor which is also known as Rb1. Rb1 functions as a transcription factor that controls cell cycle progression (at the G1/S phase transition) through its repression of E2F-mediated transcription. Mutation of the Rb gene is found frequently in human sarcomas, lung, bladder and breast carcinomas and is the molecular basis for hereditary disposition to retinoblastoma.

Aufreinigung: Purified on protein A from tissue culture supernatant.

Immunogen: Rb-b-galactosidase fusion protein spanning nucleotides 1126-1973 of human Rb gel purified from bacterial lysates

Klon: 1F8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal antibody dilution should be determined by titration

Kommentare:

Myeloma, fusion partnersCells from immunized Balb/c mice were fused with the Sp2/0-Ag.14 myeloma cell line

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Purified IgG conjugated to Horseradish Peroxidase using Innova Biosciences Lightning-Link ®, supplied in Phosphate buffered saline (PBS) containing 0.01 % Thiomersal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu Retinoblastoma 1

Target: Retinoblastoma 1 (RB1)

Andere Bezeichnung: Rb1 (RB1 Produkte)

Gen-ID: 5925, 19645

OMIM: 614041

Pathways: Zellzyklus, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagie