IL-8 Antikörper (HRP)

Produktnummer ABIN453903

Der HRP-konjugierte Maus Monoklonal anti-IL-8 Antikörper (Klon I8-60) (ABIN453903) detektiert spezifisch IL-8 in EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für IL-8 Antikörper (HRP) (ABIN453903)

Target: IL-8 (IL8) (Interleukin 8 (IL8))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL-8 Antikörper ist konjugiert mit HRP

Applikation: Enzyme Immunoassay (EIA)

Klon: I8-60

Produktdetails anti-IL-8 Antikörper (HRP)

Spezifität: This antibody recognizes both, natural and recombinant IL-8. No cross-reactivity with human monocyte chemotactic activating factor (MCP-1) or RANTES (Regulated on Activation, Normal T-cell Expressed, and Secreted)

Aufreinigung: Affinity chromatography on Protein G

Immunogen: Purified recombinant human IL-8 (monocyte-derive, 72-amino acid form)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 M PBS, pH 7.0 ± 0.1 in 50 % Glycerol and 0.01 % thimerosal as a bacteriostat

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu IL-8

Target: IL-8 (IL8) (Interleukin 8 (IL8))

Andere Bezeichnung: Interleukin-8 / IL8

Hintergrund: IL8 is a member of the CXC chemokine family. This family of small basic heparan-binding proteins are proinflammatory and primarily mediate the activation and migration of neutrophils into tissue from peripheral blood. This chemokine is one of the major mediators of the inflammatory response and is secreted by several cell types in response to an inflammatory stimulus. It functions as a chemoattractant, and is also a potent angiogenic factor. IL8 attracts neutrophils, basophils, and T-cells, but not monocytes. Cystic fibrosis (CF) is characterized by severe lung inflammation. The inflammatory process is believed to be caused by massive overproduction of the proinflammatory protein IL8, and the high levels of IL8 in the CF lung are therefore believed to be the central mechanism behind CF lung pathophysiology.Synonyms: CXCL8, Emoctakin, GCP1, Granulocyte chemotactic protein 1, MDNCF, MONAP, Monocyte-derived neutrophil chemotactic factor, Monocyte-derived neutrophil-activating peptide, NAP1, Neutrophil-activating protein 1, Protein 3-10C, T-cell chemotactic factor

Gen-ID: 3576

NCBI Accession: NP_000575

UniProt: P10145

Pathways: TLR Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Hepatitis C, Autophagie