NOD1 Antikörper (C-Term)

Produktnummer ABIN453551

Der Kaninchen Polyklonal anti-NOD1 Antikörper wird verwendet zum Nachweis von NOD1 in Proben von Human. Er wurde validiert für WB, IHC (p) und EIA.

Kurzübersicht für NOD1 Antikörper (C-Term) (ABIN453551)

Target: NOD1 (Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-NOD1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody recognizes CARD4 / NOD1 (C-term).

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography on Protein A.

Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of Human CARD4. Genename: NOD1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu NOD1

Target: NOD1 (Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1))

Andere Bezeichnung: CARD4 / NOD1

Hintergrund: CARD4 is a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.Synonyms: Caspase recruitment domain-containing protein 4, Nucleotide-binding oligomerization domain-containing protein 1

Molekulargewicht: 107691 Da

Gen-ID: 10392

NCBI Accession: NP_006083

UniProt: Q9Y239

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades, Inflammasome