UBE2N Antikörper (AA 40-51)

Produktnummer ABIN401175

Produktdetails anti-UBE2N Antikörper

Target: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Bindungsspezifität: AA 40-51

Reaktivität: Human, Ratte, Maus, Zebrafisch (Danio rerio), Hund, Rind (Kuh), Huhn, Xenopus laevis, Schimpanse, Makake

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser UBE2N Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody is directed against UBC13 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Canine, Bovine, Xenopus laevis, Xenopus tropicalis, Zebrafish, Rat, Mouse, Chimpanzee, Macaque, Chicken.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Immunogen: Synthetic peptide corresponding to amino acids 40-51 of human UBC13 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/5,000 - 1/25,000. Western Blot: 1/500 - 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.25 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu UBE2N

Target: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Abstract: UBE2N Produkte

Synonyme: UBC13 antikoerper, UbcH-ben antikoerper, UbcH13 antikoerper, 1500026J17Rik antikoerper, AL022654 antikoerper, BB101821 antikoerper, ube2n antikoerper, wu:fb11b03 antikoerper, wu:fc08b06 antikoerper, zgc:55726 antikoerper, ubc13 antikoerper, ubch-ben antikoerper, UBE2N antikoerper, ube2nl antikoerper, zgc:63901 antikoerper, ubiquitin conjugating enzyme E2 N antikoerper, ubiquitin-conjugating enzyme E2N antikoerper, ubiquitin conjugating enzyme E2 N S homeolog antikoerper, ubiquitin-conjugating enzyme E2Na antikoerper, ubiquitin-conjugating enzyme E2Nb antikoerper, UBE2N antikoerper, Ube2n antikoerper, ube2n.S antikoerper, ube2na antikoerper, LOC100533434 antikoerper, ube2n antikoerper, ube2nb antikoerper

Hintergrund: UBC13 is a member of the E2 ubiquitin-conjugating enzyme family also known as Ubiquitin-conjugating enzyme E2 N, Ubiquitin-protein ligase N, Ubiquitin carrier protein N and Bendless-like ubiquitin-conjugating enzyme. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. UBC13 forms a heterodimer with UBE2V2 which then catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of polyubiquitination does not lead to protein degradation by the proteasome. UBC13 also mediates transcriptional activation of target genes and plays a role in the control of progress through the cell cycle and differentiation, as well as error-free DNA repair. UBC13 also contributes to the survival of cells after DNA damage.Synonyms: Bendless-like ubiquitin-conjugating enzyme, UBC13, Ubiquitin carrier protein N, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-protein ligase N

Gen-ID: 7334

NCBI Accession: NP_003339

UniProt: P61088

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Positive Regulation of Response to DNA Damage Stimulus, Ubiquitin Proteasome Pathway