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EGFR Antikörper (pTyr1197)

Name: EGFR Antikörper (pTyr1197)
SKU: ABIN400879
Price: 660 EUR
Availability: InStock

EGFR Reaktivität: Human WB, FACS, IP Wirt: Maus Monoclonal EM-13 unconjugated

Western Blotting (WB) image for anti-Epidermal Growth Factor Receptor (EGFR) (pTyr1197) antibody (ABIN400879) (EGFR Antikörper (pTyr1197))

3 Abbildungen

Produktnummer ABIN400879

Datenblatt (PDF)

Target Alle EGFR Antikörper anzeigen

EGFR (Epidermal Growth Factor Receptor (EGFR))
Bindungsspezifität
39

37

31

31

30

28

27

26

25

22

21

18

16

16

16

15

15

15

11

11

10

9

9

9

8

8

7

6

5

5

5

4

4

4

4

4

4

4

4

3

3

3

3

3

3

3

3

3

3

3
pTyr1197
Reaktivität
756

299

287

25

25

24

20

14

8

3

2

2

1

1

1

1

1

1
Human
Wirt
580

177

14

13

5

1

1
Maus
Passende Sekundärantikörper
Klonalität
542

244

2
Monoklonal
Konjugat
410

58

29

22

20

18

18

17

16

16

16

12

10

10

10

10

10

10

10

10

10

8

8

5

4

4

4

4

4

2

1

1

1

1

1

1
Dieser EGFR Antikörper ist unkonjugiert
Applikation
535

245

149

149

129

102

100

93

82

46

37

34

34

19

11

8

6

4

4

3

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)

Spezifität

The antibody EM-13 reacts with EGFR (ErbB1 / HER1) phosphorylated on tyrosine 1197.

Kreuzreaktivität (Details)

Species reactivity (tested):Human.

Produktmerkmale

Synonyms: Epidermal growth factor receptor, EGF Receptor, erbB-1, c-ErbB-1, Receptor tyrosine-proteinkinase erbB-1, Proto-oncogene c-ErbB-1

Aufreinigung

Protein-A affinity chromatography

Reinheit

> 95 % pure by SDS-PAGE

Immunogen

Synthetic phospho-peptide covering sequence around tyrosine 1197 of human EGFR

Klon

EM-13

Isotyp

IgG1

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Applikationshinweise

Flow cytometry. Immunoprecipitation. Western blot: 1 μg/mL. Positive control: EGF-stimulated A431. Negative control: Non-stimulated A431.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1.0 mg/mL

Buffer

Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C

Informationen zur Lagerung

Store at 2-8 °C for up to one month or at -20 °C for longer. Avoid repeated freezing andthawing.
Shelf life: One year from despatch.

Haltbarkeit

12 months
Target

EGFR (Epidermal Growth Factor Receptor (EGFR))

Andere Bezeichnung

EGFR / ERBB1 (EGFR Produkte)

Hintergrund

The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.Synonyms: EGF Receptor, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, c-ErbB-1, erbB-1

Gen-ID

1956

UniProt

P00533

Pathways

NF-kappaB Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteine