TBK1 Antikörper (AA 563-577)

Produktnummer ABIN400648

Dieser Maus Monoklonal Antikörper detektiert spezifisch TBK1 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh) und Hund.

Kurzübersicht für TBK1 Antikörper (AA 563-577) (ABIN400648)

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TBK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 108A429

Produktdetails anti-TBK1 Antikörper

Bindungsspezifität: AA 563-577

Spezifität: This antibody recognizes Human TANK-Binding Kinase 1 (TBK1/NAK).

Kreuzreaktivität (Details): Species reactivity (expected):Bovine, Canine (Dog), Mouse and Rat.
Species reactivity (tested):Human.

Produktmerkmale: Synonyms: NAK, TANK-binding kinase 1, T2K, NF-kappa-B-activating kinase

Aufreinigung: Protein G Chromatography

Immunogen: A synthetic peptide corresponding to amino acids 563-577 of Human TBK1 - KLHconjugated. AA Sequence: YYQFKKDKAERRLAYCRemarks: This sequence is 100% conserved between Human, Mouse, Rat, Dog and Cow.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot: 1-2 μg/mL. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS, 0.05 % Sodium Azide, 0.2 % Gelatin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu TBK1

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Andere Bezeichnung: TBK1

Hintergrund: NFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor-associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family. Similar to IKK alpha and beta, NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumour promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536. NAK is also known to interact with TANK, TRAF-2 and TRIF.Synonyms: NAK, NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1

Gen-ID: 29110

UniProt: Q9UHD2

Pathways: TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interaktom