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Hexokinase 1 Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-Hexokinase 1-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, Hexokinase 1 in Proben von Human und Ratte zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN392759

Kurzübersicht für Hexokinase 1 Antikörper (N-Term) (ABIN392759)

Target

Alle Hexokinase 1 (HK1) Antikörper anzeigen
Hexokinase 1 (HK1)

Reaktivität

  • 101
  • 62
  • 42
  • 7
  • 6
  • 6
  • 5
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Ratte

Wirt

  • 116
  • 17
Kaninchen

Klonalität

  • 107
  • 26
Polyklonal

Konjugat

  • 81
  • 20
  • 8
  • 5
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser Hexokinase 1 Antikörper ist unkonjugiert

Applikation

  • 108
  • 69
  • 43
  • 36
  • 31
  • 21
  • 15
  • 11
  • 7
  • 5
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB3921-RB3922
  • Bindungsspezifität

    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 78-108, N-Term

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This HK1 (Hexokinase) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-108 amino acids from the N-terminal region of human HK1 (Hexokinase).

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. WB: 1:2000. WB: 1:1000. WB: 1:1000. IHC-P-Leica: 1:500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Lynn, Wang, Markesbery, Lovell: "Quantitative changes in the mitochondrial proteome from subjects with mild cognitive impairment, early stage, and late stage Alzheimer's disease." in: Journal of Alzheimer's disease : JAD, Vol. 19, Issue 1, pp. 325-39, (2010) (PubMed).

  • Target

    Hexokinase 1 (HK1)

    Andere Bezeichnung

    HK1 (Hexokinase)

    Hintergrund

    Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. The hexokinase gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of the hexokinase gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus, the remainder of the protein is identical among all the isoforms. HK1 encodes the ubiquitously expressed isoform. Its 5' end includes an exon which is unique to this transcript and which encodes a distinct N-terminus that contains the porin binding domain (PBD). The porin binding domain mediates association with the mitochondrial membrane.

    Molekulargewicht

    102486

    Gen-ID

    3098

    NCBI Accession

    NP_000179, NP_277031, NP_277032, NP_277033, NP_277035

    UniProt

    P19367

    Pathways

    Carbohydrate Homeostasis, Warburg Effekt
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