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MAP3K8 Antikörper (C-Term)

MAP3K8 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB03467 unconjugated
Produktnummer ABIN392472
  • Target Alle MAP3K8 Antikörper anzeigen
    MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
    Bindungsspezifität
    • 19
    • 12
    • 9
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 368-397, C-Term
    Reaktivität
    • 86
    • 41
    • 39
    • 7
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 85
    • 1
    Kaninchen
    Klonalität
    • 85
    • 1
    Polyklonal
    Konjugat
    • 37
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAP3K8 Antikörper ist unkonjugiert
    Applikation
    • 54
    • 40
    • 29
    • 16
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    M, Rat
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This COT (MAP3K8/MEKK8) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-397 amino acids from the C-terminal region of human COT (MAP3K8/MEKK8).
    Klon
    RB03467
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product MAP3K8 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
    Andere Bezeichnung
    COT (MAP3K8/MEKK8) (MAP3K8 Produkte)
    Synonyme
    MAP3K8 antikoerper, COT antikoerper, EST antikoerper, ESTF antikoerper, MEKK8 antikoerper, TPL2 antikoerper, Tpl-2 antikoerper, c-COT antikoerper, Cot antikoerper, Cot/Tpl2 antikoerper, Est antikoerper, Estf antikoerper, Tpl2 antikoerper, D17TPL2 antikoerper, mitogen-activated protein kinase kinase kinase 8 antikoerper, MAP3K8 antikoerper, map3k8 antikoerper, Map3k8 antikoerper
    Hintergrund
    COT, a member of the MAPKKK subfamily of Ser/Thr protein kinases, is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. It plays a role in the cell cycle. The longer form of cot has some transforming activity, although it is much weaker than the activated cot oncoprotein. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.
    Molekulargewicht
    52925
    Gen-ID
    1326
    NCBI Accession
    NP_001231063, NP_005195
    UniProt
    P41279
    Pathways
    PI3K-Akt Signalweg, T-Zell Rezeptor Signalweg
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