MAP3K8 Antikörper (pThr290)

Produktnummer ABIN389798

Produktdetails anti-MAP3K8 Antikörper

Target: MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))

Bindungsspezifität: pThr290

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP3K8 Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MAP3K8 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T290 of human MAP3K8.

Klon: RB11315

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu MAP3K8

Target: MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))

Andere Bezeichnung: MAP3K8 (MAP3K8 Produkte)

Synonyme: MAP3K8 antikoerper, COT antikoerper, EST antikoerper, ESTF antikoerper, MEKK8 antikoerper, TPL2 antikoerper, Tpl-2 antikoerper, c-COT antikoerper, Cot antikoerper, Cot/Tpl2 antikoerper, Est antikoerper, Estf antikoerper, Tpl2 antikoerper, D17TPL2 antikoerper, mitogen-activated protein kinase kinase kinase 8 antikoerper, MAP3K8 antikoerper, map3k8 antikoerper, Map3k8 antikoerper

Hintergrund: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK8 is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. The protein appears to play an important role in the cell cycle. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.

Molekulargewicht: 52925

Gen-ID: 1326

NCBI Accession: NP_001231063, NP_005195

UniProt: P41279

Pathways: PI3K-Akt Signalweg, T-Zell Rezeptor Signalweg