EPH Receptor B4 Antikörper

Produktnummer ABIN391924

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch EPH Receptor B4 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für EPH Receptor B4 Antikörper (ABIN391924)

Target: EPH Receptor B4 (EPHB4)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor B4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB14731

Produktdetails anti-EPH Receptor B4 Antikörper

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This EphB4 antibody is generated from rabbits immunized with human recombinant EphB4 protein.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-EPH Receptor B4 Antikörper (ABIN391924)

Aslam, Abraham, Mansoor, Druker, Tyner, Keller: "PDGFR? reverses EphB4 signaling in alveolar rhabdomyosarcoma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 17, pp. 6383-8, (2014) (PubMed).

Brantley-Sieders, Jiang, Sarma, Badu-Nkansah, Walter, Shyr, Chen: "Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome." in: PLoS ONE, Vol. 6, Issue 9, pp. e24426, (2011) (PubMed).

Details zu EPH Receptor B4

Target: EPH Receptor B4 (EPHB4)

Andere Bezeichnung: EphB4

Hintergrund: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.

Molekulargewicht: 108270

Gen-ID: 2050

NCBI Accession: NP_004435

UniProt: P54760

Pathways: RTK Signalweg