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CDK4 Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-CDK4-Antikörper wurde für WB, IF, FACS und IHC (p) validiert. Er ist geeignet, CDK4 in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.
Produktnummer ABIN391751

Kurzübersicht für CDK4 Antikörper (C-Term) (ABIN391751)

Target

Alle CDK4 Antikörper anzeigen
CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

Reaktivität

  • 121
  • 72
  • 55
  • 19
  • 8
  • 7
  • 4
  • 4
  • 3
  • 1
  • 1
  • 1
Human

Wirt

  • 103
  • 38
  • 2
  • 1
Kaninchen

Klonalität

  • 98
  • 45
Polyklonal

Konjugat

  • 91
  • 10
  • 9
  • 5
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CDK4 Antikörper ist unkonjugiert

Applikation

  • 121
  • 49
  • 34
  • 34
  • 25
  • 23
  • 23
  • 14
  • 13
  • 10
  • 7
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB03154
  • Bindungsspezifität

    • 17
    • 16
    • 14
    • 9
    • 9
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 273-305, C-Term

    Aufreinigung

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    Immunogen

    This CDK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-305 amino acids from the C-terminal region of human CDK4.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100. FC: 1:10~50

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Ling, Song, Fan, Feng, Liu, Yang, Wang, Li, Tian, Zhao, Liu, Huang, Hou, Xu, Shi, Li: "Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway." in: International journal of oncology, Vol. 50, Issue 1, pp. 297-309, (2017) (PubMed).

    Patel, Asbach, Shteyn, Gomez, Coltoff, Bhuyan, Tyner, Wagner, Blain: "Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4." in: Molecular and cellular biology, Vol. 35, Issue 9, pp. 1506-22, (2015) (PubMed).

    Ling, Feng, Ke, Fan, Li, Li, Dong, Wang, Xu, Li, Wang: "Metformin inhibits proliferation and enhances chemosensitivity of intrahepatic cholangiocarcinoma cell lines." in: Oncology reports, Vol. 31, Issue 6, pp. 2611-8, (2014) (PubMed).

  • Target

    CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

    Andere Bezeichnung

    CDK4

    Hintergrund

    CDK4 is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of the gene have been reported.

    Molekulargewicht

    33730

    Gen-ID

    1019

    NCBI Accession

    NP_000066

    UniProt

    P11802

    Pathways

    Zellzyklus, Mitotic G1-G1/S Phases, Regulation of Cell Size
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