PKM2 Antikörper (C-Term)

Produktnummer ABIN391053

Dieses Anti-PKM2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PKM2 in WB, IHC (p) und IF. Geeignet für Human, Maus, Ratte und Affe. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für PKM2 Antikörper (C-Term) (ABIN391053)

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Klon: RB3697

Produktdetails anti-PKM2 Antikörper

Bindungsspezifität: AA 476-505, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Pyruvate Kinase (PKM2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-505 amino acids from the C-terminal region of human Pyruvate Kinase (PKM2).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:200. WB: 1:1000. WB: 1:1000. WB: 1:2000. IHC-P: 1:50~1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-PKM2 Antikörper (ABIN391053)

Kienzl, Sarg, Golderer, Obrist, Werner, Werner-Felmayer, Lindner, Maglione, Schneeberger, Margreiter, Brandacher: "Proteomic profiling of acute cardiac allograft rejection." in: Transplantation, Vol. 88, Issue 4, pp. 553-60, (2009) (PubMed).

Details zu PKM2

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Andere Bezeichnung: PKM2

Hintergrund: There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. PKM2 is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. This protein has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis.

Molekulargewicht: 57937

Gen-ID: 5315

NCBI Accession: NP_001193725, NP_001193726, NP_001193727, NP_001193728, NP_002645, NP_872270, NP_872271

UniProt: P14618

Pathways: Warburg Effekt