PINK1 Antikörper (N-Term)

Produktnummer ABIN390369

Dieses Anti-PINK1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PINK1 in WB und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für PINK1 Antikörper (N-Term) (ABIN390369)

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PINK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB07381

Produktdetails anti-PINK1 Antikörper

Bindungsspezifität: AA 118-147, N-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-147 amino acids from the N-terminal region of human PINK1 (PARK6).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PINK1 Antikörper (ABIN390369)

Wang, Hu, Zou, Xiang, Jiang, Botchway, Huo, Du, Fang: "The post-therapeutic effect of rapamycin in mild traumatic brain-injured rats ensuing in the upregulation of autophagy and mitophagy." in: Cell biology international, Vol. 41, Issue 9, pp. 1039-1047, (2018) (PubMed).

Zhang, Gu, Chen, Ni, Hung, Wang, Zhang, Feng, Ji: "High expression of PINK1 promotes proliferation and chemoresistance of NSCLC." in: Oncology reports, Vol. 37, Issue 4, pp. 2137-2146, (2017) (PubMed).

Details zu PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Andere Bezeichnung: PINK1 (PARK6)

Hintergrund: Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.

Molekulargewicht: 62769

Gen-ID: 65018

NCBI Accession: NP_115785

UniProt: Q9BXM7

Pathways: Autophagie