AGR2 Antikörper (AA 95-124)

Produktnummer ABIN390227

Der Kaninchen Polyklonal Anti-AGR2-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, AGR2 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für AGR2 Antikörper (AA 95-124) (ABIN390227)

Target: AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AGR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB13858

Produktdetails anti-AGR2 Antikörper

Bindungsspezifität: AA 95-124

Homologie: Zf, M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This AGR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the Central region of human AGR2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-AGR2 Antikörper (ABIN390227)

Guo, Chen, Zhu, Yu, Rong, Merugu, Mangukiya, Li: "A humanized monoclonal antibody targeting secreted anterior gradient 2 effectively inhibits the xenograft tumor growth." in: Biochemical and biophysical research communications, Vol. 475, Issue 1, pp. 57-63, (2017) (PubMed).

Guo, Zhu, Yu, Merugu, Mangukiya, Smith, Li, Zhang, Negi, Rong, Cheng, Wu, Li: "Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization." in: Oncogene, Vol. 36, Issue 36, pp. 5098-5109, (2017) (PubMed).

Details zu AGR2

Target: AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

Andere Bezeichnung: Anterior Gradient 2 (AGR2)

Hintergrund: Anterior gradient 2 (AGR2) is known as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. AGR2 has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells (CTCs). Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells, but conditions leading to increased expression of AGR2 are not well understood.

Molekulargewicht: 19979

Gen-ID: 10551

NCBI Accession: NP_006399

UniProt: O95994