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AGR2 Antikörper (AA 95-124)

This anti-AGR2 antibody (ABIN390227) is a Rabbit Polyclonal antibody detecting AGR2 in WB, IHC (p). Suitable for Human.
Produktnummer ABIN390227

Kurzübersicht für AGR2 Antikörper (AA 95-124) (ABIN390227)

Target

Alle AGR2 Antikörper anzeigen
AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

Reaktivität

  • 75
  • 39
  • 36
  • 6
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 83
  • 28
  • 1
  • 1
  • 1
Kaninchen

Klonalität

  • 77
  • 36
Polyklonal

Konjugat

  • 66
  • 14
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser AGR2 Antikörper ist unkonjugiert

Applikation

  • 90
  • 60
  • 37
  • 30
  • 29
  • 19
  • 14
  • 14
  • 14
  • 5
  • 4
  • 4
  • 2
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB13858
  • Bindungsspezifität

    • 28
    • 15
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 95-124

    Homologie

    Zf, M

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This AGR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the Central region of human AGR2.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Guo, Chen, Zhu, Yu, Rong, Merugu, Mangukiya, Li: "A humanized monoclonal antibody targeting secreted anterior gradient 2 effectively inhibits the xenograft tumor growth." in: Biochemical and biophysical research communications, Vol. 475, Issue 1, pp. 57-63, (2017) (PubMed).

    Guo, Zhu, Yu, Merugu, Mangukiya, Smith, Li, Zhang, Negi, Rong, Cheng, Wu, Li: "Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization." in: Oncogene, Vol. 36, Issue 36, pp. 5098-5109, (2017) (PubMed).

  • Target

    AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

    Andere Bezeichnung

    Anterior Gradient 2 (AGR2)

    Hintergrund

    Anterior gradient 2 (AGR2) is known as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. AGR2 has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells (CTCs). Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells, but conditions leading to increased expression of AGR2 are not well understood.

    Molekulargewicht

    19979

    Gen-ID

    10551

    NCBI Accession

    NP_006399

    UniProt

    O95994
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