WISP3 Antikörper (AA 305-335)

Produktnummer ABIN390189

Dieses Anti-WISP3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von WISP3 in WB und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für WISP3 Antikörper (AA 305-335) (ABIN390189)

Target: WISP3 (Wnt1 Inducible Signaling Pathway Protein 3 (WISP3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WISP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB2145-2146

Produktdetails anti-WISP3 Antikörper

Bindungsspezifität: AA 305-335

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This WISP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-335 amino acids from the Central region of human WISP3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-WISP3 Antikörper (ABIN390189)

Ji, Jia, Jia, Ji, Hargest, Jiang: "WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-? pathways." in: British journal of cancer, Vol. 113, Issue 6, pp. 921-33, (2015) (PubMed).

Details zu WISP3

Target: WISP3 (Wnt1 Inducible Signaling Pathway Protein 3 (WISP3))

Andere Bezeichnung: WISP3

Hintergrund: WISP3 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP3 is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of the WISP3 gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis.

Molekulargewicht: 39293

Gen-ID: 8838

NCBI Accession: NP_003871, NP_937882

UniProt: O95389

Pathways: WNT Signalweg, Growth Factor Binding