NOTCH3 Antikörper (C-Term)

Produktnummer ABIN390159

Dieses Anti-NOTCH3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von NOTCH3 in WB, IF und IHC (p). Geeignet für Maus. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für NOTCH3 Antikörper (C-Term) (ABIN390159)

Target: NOTCH3 (Notch 3 (NOTCH3))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOTCH3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB02199

Produktdetails anti-NOTCH3 Antikörper

Bindungsspezifität: AA 2291-2321, C-Term

Homologie: H

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This NOTCH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-NOTCH3 Antikörper (ABIN390159)

Liu, Yang, Wang, Miao, Liu, Li, Zou, Li, Liang, Zeng, Chen: "The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance." in: Pathology oncology research : POR, Vol. 22, Issue 3, pp. 483-92, (2017) (PubMed).

Details zu NOTCH3

Target: NOTCH3 (Notch 3 (NOTCH3))

Andere Bezeichnung: NOTCH3

Hintergrund: NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Molekulargewicht: 243631

Gen-ID: 4854

NCBI Accession: NP_000426

UniProt: Q9UM47

Pathways: Notch Signalweg