PAK1 Antikörper (pThr423)

Produktnummer ABIN389799

Dieses Anti-PAK1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PAK1 in WB und IF. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für PAK1 Antikörper (pThr423) (ABIN389799)

Target: PAK1 (P21-Activated Kinase 1 (PAK1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: RB11381

Produktdetails anti-PAK1 Antikörper

Bindungsspezifität: pThr423

Homologie: B, M, Rat, Rb, X

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PAK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T423 of human PAK1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:500. IF: 1:10~50. DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PAK1 Antikörper (ABIN389799)

Zhang, Li, Liu, Cao, Chen, Liu, Wang, Du, Weng, Ma: "p21-activated kinase 1 activity is required for histone H3 Ser10 phosphorylation and chromatin condensation in mouse oocyte meiosis." in: Reproduction, fertility, and development, Vol. 29, Issue 7, pp. 1287-1296, (2018) (PubMed).

El-Baba, Mahadevan, Fahlbusch, S, Rau, Gali-Muhtasib, Schneider-Stock: "Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer." in: Molecular cancer, Vol. 13, pp. 201, (2014) (PubMed).

Details zu PAK1

Target: PAK1 (P21-Activated Kinase 1 (PAK1))

Andere Bezeichnung: PAK1

Hintergrund: PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology.

Molekulargewicht: 60647

Gen-ID: 5058

NCBI Accession: NP_001122092, NP_002567

UniProt: Q13153

Pathways: MAPK Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Embryonic Body Morphogenesis