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Retinoblastoma 1 Antikörper (pSer788)

Name: Retinoblastoma 1 Antikörper (pSer788)
SKU: ABIN389645
Price: 467.5 EUR
Availability: InStock

RB1 Reaktivität: Human IHC (p), DB Wirt: Kaninchen Polyclonal RB7670 unconjugated

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (Retinoblastoma 1 Antikörper (pSer788))

IHC (p)

Dot blot analysis of anti-hRb- Phospho-specific Pab (ABIN389645 and ABIN2839637) on nitrocellulose membrane. (Retinoblastoma 1 Antikörper (pSer788))

2 Abbildungen

(1 reference)

Produktnummer ABIN389645

Datenblatt (PDF)

Target Alle Retinoblastoma 1 (RB1) Antikörper anzeigen

Retinoblastoma 1 (RB1)
Bindungsspezifität
31

22

20

19

18

17

15

15

6

6

4

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer788
Reaktivität
241

114

98

6

4

4

3

3

3

2

2

1

1

1
Human
Wirt
205

39
Kaninchen
Passende Sekundärantikörper
Klonalität
195

49
Polyklonal
Konjugat
134

8

7

6

6

6

6

6

6

6

6

6

6

6

6

4

4

2

2

2

2

1

1

1

1

1

1

1
Dieser Retinoblastoma 1 Antikörper ist unkonjugiert
Applikation
194

80

79

67

63

39

30

28

21

17

9

9

8

6

6

6

4

2

1
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)

Spezifität

This Phospho-Rb-S788 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S788 of human Rb.

Aufreinigung

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen

This Rb Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S788 of human Rb.

Klon

RB7670

Isotyp

Ig Fraction

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anti-Retinoblastoma 1 (RB1) (pSer780) antibody
RB1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (C-Term) antibody
RB1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

DB = 1:500, IHC (p) = 1:50-100

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

0.45 mg/mL

Buffer

PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C/-20 °C

Informationen zur Lagerung

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit

6 months
Iwahori, Hakki, Chou, Kalejta: "Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97." in: The Journal of biological chemistry, Vol. 290, Issue 32, pp. 19666-80, (2015) (PubMed).
Target

Retinoblastoma 1 (RB1)

Andere Bezeichnung

Rb (RB1 Produkte)

Hintergrund

RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.
Synonyms: Retinoblastoma-associated protein, PP110, P105-RB, RB, RB1,

Molekulargewicht

106159 DA

Gen-ID

5925

UniProt

P06400

Pathways

Zellzyklus, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagie